You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page.
Turn on more accessible mode
Turn off more accessible mode
Skip Ribbon Commands
Skip to main content
Turn off Animations
Turn on Animations
To navigate through the Ribbon, use standard browser navigation keys. To skip between groups, use Ctrl+LEFT or Ctrl+RIGHT. To jump to the first Ribbon tab use Ctrl+[. To jump to the last selected command use Ctrl+]. To activate a command, use Enter.
Browse
Tab 1 of 3.
List Tools
Items
List Tools group. Tab 2 of 3.
List
List Tools group. Tab 3 of 3.
Follow
Dr. Mohammad Alsalem
Currently selected
MY CV
About Me
Contact Me
Office Hours
Research Interests
It looks like your browser does not have JavaScript enabled. Please turn on JavaScript and try again.
Academic Information
Research Interests
Currently selected
Published Research
Published Books
Patency
Academic Conferences
Theses/Dissertations Supervision
Award/Prizes/Orders
Funded Research/Project
Taught Courses
Ongoing Research
Other Academic Activities
Main Menu
News
Announcements
Calendar
Documents
Useful Links
My Documents
My Contacts
My Gallery
Courses
Materials
Homeworks
About Me
Contact Me
Office Hours
Site Contents
Research Interests
Details
Analgesic effects of cannabinoids in a rat model of osteoarthritis and the role of PPARs in mediating these analgesic properties.
Osteoarthritis is slowly progressive disease characterized by destruction of articular cartilage , subchondral bone sclerosis , and chronic inflammation of the synovium . Symptoms usually manifest as pain, stiffness, swelling and crepitus. Currently, analgesic treatments for osteoarthritis have limited efficacy and accompanied by gastrointestinal and cardiovascular side effects. Cannabinoids are a group of compounds structurally related to Δ9-tetrahydrocannabinol (Δ9-THC), a substance found in the Cannabis sativa plant which has been used for centuries for its psychoactive and medicinal effects. Considering the physiological role of cannabinoid receptors (CB1 And CB2) in controlling multiple responses including pain and inflammation, cannabinoids exert analgesic effects in rodent models of osteoarthritis. However, previous studies have shown that cannabinoids and cannabinoid like-compounds could produce analgesia in a CB1/CB2 independent fashion by interaction with other receptors such as The transient receptor potential vanilloid (TRPV1) and peroxisome proliferator-activated receptors (PPARs). PPARs are nuclear receptors activated by fatty acids, eicosanoids and synthetic agonists. Three PPAR isoforms have been identified—α, β/δ, and γ. PPARs are involved in controlling lipid metabolism, inflammatory and immune responses. Several studies have confirmed the ability of PPAR ligands to inhibit the signaling pathways of joint inflammation and reduce the formation of cartilage catabolic factors. Yet, the analgesic properties of PPAR ligands in osteoarthritis are less clear. My research interest is using rat models of osteoarthritis and molecular biology techniques to investigate the possible role of PPAR receptors in mediating the analgesic effects of different cannabinoids such as WIN-55,212-2, HU210 and cannabinoid-like compounds such as Palmitoylethanolamide (PEA).
Follow
javascript: SP.SOD.executeFunc('followingcommon.js', 'FollowDoc', function() { FollowDoc('{ListId}', {ItemId}); });
0x0
0x0
ContentType
0x01
1100
Compliance Details
javascript:if (typeof CalloutManager !== 'undefined' && Boolean(CalloutManager) && Boolean(CalloutManager.closeAll)) CalloutManager.closeAll(); commonShowModalDialog('{SiteUrl}'+ '/_layouts/15/itemexpiration.aspx' +'?ID={ItemId}&List={ListId}', 'center:1;dialogHeight:500px;dialogWidth:500px;resizable:yes;status:no;location:no;menubar:no;help:no', function GotoPageAfterClose(pageid){if(pageid == 'hold') {STSNavigate(unescape(decodeURI('{SiteUrl}'))+ '/_layouts/15/hold.aspx' +'?ID={ItemId}&List={ListId}'); return false;} if(pageid == 'audit') {STSNavigate(unescape(decodeURI('{SiteUrl}'))+ '/_layouts/15/Reporting.aspx' +'?Category=Auditing&backtype=item&ID={ItemId}&List={ListId}'); return false;} if(pageid == 'config') {STSNavigate(unescape(decodeURI('{SiteUrl}'))+ '/_layouts/15/expirationconfig.aspx' +'?ID={ItemId}&List={ListId}'); return false;}}, null);
0x0
0x1
ContentType
0x01
898
Document Set Version History
/_layouts/15/images/versions.gif?rev=40
javascript:SP.UI.ModalDialog.ShowPopupDialog('{SiteUrl}'+ '/_layouts/15/DocSetVersions.aspx' + '?List={ListId}&ID={ItemId}')
0x0
0x0
ContentType
0x0120D520
330
Send To other location
/_layouts/15/images/sendOtherLoc.gif?rev=40
javascript:GoToPage('{SiteUrl}' + '/_layouts/15/docsetsend.aspx' + '?List={ListId}&ID={ItemId}')
0x0
0x0
ContentType
0x0120D520
350